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Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway.
Feng Z, Wang T, Sun Y, Chen S, Hao H, Du W, Zou H, Yu D, Zhu H, Pang Y. Feng Z, et al. Ecotoxicol Environ Saf. 2023 Apr 1;254:114747. doi: 10.1016/j.ecoenv.2023.114747. Epub 2023 Mar 10. Ecotoxicol Environ Saf. 2023. PMID: 36907095 Free article.
SFN also effectively inhibited PQ-mediated increase in BAX and CASPASE-3 protein expressions. ...Collectively, these findings provide novel evidence for the protective role of SFN in alleviating PQ-caused injury, and suggest that SFN application may be …
SFN also effectively inhibited PQ-mediated increase in BAX and CASPASE-3 protein expressions. ...Collectively, these findings …
Sulforaphane alleviates lung ischemia‑reperfusion injury through activating Nrf‑2/HO‑1 signaling.
Zhang L, Wang S, Zhang Y, Li F, Yu C. Zhang L, et al. Exp Ther Med. 2023 Apr 20;25(6):265. doi: 10.3892/etm.2023.11964. eCollection 2023 Jun. Exp Ther Med. 2023. PMID: 37206558 Free PMC article.
The present study hypothesized that SFN may protect against lung I/R injury via the regulation of antioxidant and anti-inflammatory-related pathways. ...In addition, SFN ameliorated I/R-induced lung apoptosis in rats by suppressing Bax and cleaved caspase-3 l …
The present study hypothesized that SFN may protect against lung I/R injury via the regulation of antioxidant and anti-inflammatory-r …
Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells.
Geng Y, Zhou Y, Wu S, Hu Y, Lin K, Wang Y, Zheng Z, Wu W. Geng Y, et al. J Cancer. 2017 Aug 2;8(13):2456-2470. doi: 10.7150/jca.19383. eCollection 2017. J Cancer. 2017. PMID: 28900483 Free PMC article.
Pro-survival Bim downregulation was shown to induce apoptosis in response to SFN. Further, Using the ERK1/2 inhibitor, PD98059, we found that SFN upregulated Bax and downregulated Bim through the ERK1/2-dependent signaling pathway. ...These findings provided …
Pro-survival Bim downregulation was shown to induce apoptosis in response to SFN. Further, Using the ERK1/2 inhibitor, PD98059, we fo …
Dietary agents as histone deacetylase inhibitors.
Myzak MC, Ho E, Dashwood RH. Myzak MC, et al. Mol Carcinog. 2006 Jun;45(6):443-6. doi: 10.1002/mc.20224. Mol Carcinog. 2006. PMID: 16652377 Free PMC article. Review.
Butyrate, diallyl disulfide (DADS), and sulforaphane (SFN) are three dietary agents that exhibit HDAC inhibitory activity in vitro and/or in vivo, and other such dietary agents probably will be discovered that affect HDAC activity. ...An important issue for future study is …
Butyrate, diallyl disulfide (DADS), and sulforaphane (SFN) are three dietary agents that exhibit HDAC inhibitory activity in vitro an …
Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo.
Liu F, Lv RB, Liu Y, Hao Q, Liu SJ, Zheng YY, Li C, Zhu C, Wang M. Liu F, et al. Onco Targets Ther. 2020 Jun 3;13:4957-4969. doi: 10.2147/OTT.S246706. eCollection 2020. Onco Targets Ther. 2020. PMID: 32581555 Free PMC article.
The treatment also decreased the expression of the survival protein Bcl-2 and increased the expression of the proapoptotic protein Bax, which increased the Bax/Bcl-2 ratio, as well as enhanced poly ADP-ribose polymerase (PARP) cleavage. ...Cotreatment also significa …
The treatment also decreased the expression of the survival protein Bcl-2 and increased the expression of the proapoptotic protein Bax …
Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells.
Wang Y, Wu H, Dong N, Su X, Duan M, Wei Y, Wei J, Liu G, Peng Q, Zhao Y. Wang Y, et al. Sci Rep. 2021 Jan 28;11(1):2504. doi: 10.1038/s41598-021-81815-2. Sci Rep. 2021. PMID: 33510228 Free PMC article.
Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, the underlying mechanisms of the anticancer activity of SFN remain not fully understood. ...These results suggested that SFN-i …
Sulforaphane (SFN) extracted from broccoli sprout has previously been investigated for its potential properties in cancers, however, …
The Protective Effect of Sulforaphane on ER-induced Apoptosis and Inflammation in Necrotizing Enterocolitis Mice.
Wang X, Mi Y, Xiong X, Bao Z. Wang X, et al. Comb Chem High Throughput Screen. 2023;26(6):1186-1195. doi: 10.2174/1386207325666220705115007. Comb Chem High Throughput Screen. 2023. PMID: 35792122
METHODS: The newborn mice were randomly divided into control (n = 15), NEC (n = 20), and NEC+SFN (n = 18) groups. Mice in NEC and SFN+NEC groups were injected with 0.1 mul normal saline or 20 mg/kg/d SFN, respectively. ...HE staining showed that SFN al …
METHODS: The newborn mice were randomly divided into control (n = 15), NEC (n = 20), and NEC+SFN (n = 18) groups. Mice in NEC and …
Effect of sulphoraphane on newborn mouse cardiomyocytes undergoing ischaemia/reperfusion injury.
Peng N, Jin L, He A, Deng C, Wang X. Peng N, et al. Pharm Biol. 2019 Dec;57(1):753-759. doi: 10.1080/13880209.2019.1680705. Pharm Biol. 2019. PMID: 31686558 Free PMC article.
Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular disease.Objective: This study explores the mechanisms of SFN preconditioning on ischaemia/reperfusion injury (IRI).Materials and meth …
Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular …
Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3β Signaling Pathway.
Bao ZK, Mi YH, Xiong XY, Wang XH. Bao ZK, et al. Can J Gastroenterol Hepatol. 2022 May 11;2022:6529842. doi: 10.1155/2022/6529842. eCollection 2022. Can J Gastroenterol Hepatol. 2022. PMID: 35600210 Free PMC article.
SFN could inhibit TLR4 and NF-kappaB levels, decrease the release of inflammatory factors TNF-alpha and IL-6, suppress Bax expression, increase Bcl-2 expression, and inhibit apoptosis both in in vitro and in vivo models of NEC. Meanwhile, SFN regulated the ex …
SFN could inhibit TLR4 and NF-kappaB levels, decrease the release of inflammatory factors TNF-alpha and IL-6, suppress Bax exp …
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, Bi B. Zhang Z, et al. Springerplus. 2016 Feb 29;5:235. doi: 10.1186/s40064-016-1910-5. eCollection 2016. Springerplus. 2016. PMID: 27026929 Free PMC article.
Invasion inhibition effects of SFN were tested by the invasion assay. The molecular mechanisms of apoptotic effects and invasion inhibition effects of SFN were detected by western blot and gelatin zymography. ...These effects are both dose dependent. Taken together, …
Invasion inhibition effects of SFN were tested by the invasion assay. The molecular mechanisms of apoptotic effects and invasion inhi …
58 results